In India alone daily 95000 people search for ’How to Stop Snoring ?’ We are fortunate to introduce for the First time in India, a Dietary Supplement that cures Snoring, Sleep Apnea, Heart Attacks, Cerebral Stroke, Obstruction in Nasal Pathway, Noisy Breathing, Sleeping Disorder, Nasal Problems.

ROREND/ SNOOZER Supplement Format :

The supplement comes under CAPSULE format.

Ingredients :

EACH CAPSULE CONTAINS EXTRACT DERIVED FROM :

ADHATODA ZYLANICA – 100mg

ZINGIBER OFFICINALE – 100 mg

GLYCIRRHIZA GLABRA – 100 mg

PIPER LONGUM – 100 mg

AEGLE MARMELOS CORR – 100mg

ROREND/SNOOZER BENEFITS :

Enjoy better sleep. A solution that avoids Snoring Pillows, Snoring Earplugs, Snorkeling masks, Jaw Straps, Snoring Jaw straps, Nose Clips.

RECOMMENDED DOSAGE :

1 Capsule in the Morning and in the Night BEFORE Food Recommended by FSSAI the dietary supplement is non-toxic and one can enjoy healthy sleep throughout the night.

PRODUCT MONOGRAPH

Dose: 1 Capsule in the Morning & 1 Capsule in the Night 10minutes BEFORE Food. As long as they feel relieved and cured.

Introduction:

Snoring:

Snoring can be defined as a Noisy breathing through the open mouth during sleep, produced by vibrations of soft palate. Snoring is usually caused by some conditions that hinder breathing through the nose, such as common cold, allergic rhinitis, or enlarged adenoids. Snoring is more common when a person is sleeping on his or her back because in this position, the lower jaw tends to drop open. In some cases, snoring alternates with sleep apnea (temporary cessation of breathing). Snoring can sometimes be prevented by sewing an object into the right clothes near the small of the back, thus making it uncomfortable to sleep on the back. Removal of enlarged adenoids will usually cure the condition in children.

Snoring is the vibration of respiratory structures and the resulting sound, due to restricted air movement during breathing while sleeping. In some cases, the sound may be soft but in the other cases it can be loud and unpleasant.

                       Just about everyone snores occasionally even a baby or a beloved pet may snore! But snoring can affect the quantity and quality of sleep. Poor sleep can lead to daytime fatigue, irritability and increased health problems. And if the snoring is so loud that the bed partner can’t sleep, one may end up banished from the bedroom. Sleeping in separate bedrooms doesn’t have to be the remedy for snoring. In fact, there are many effective treatments for snoring. Discovering the cause of snoring and finding the right cure will vastly improve the health, your relationships and of course the sleep.

Causes:

Generally speaking, the structures involved are the UVULA and soft palate. The irregular airflow is caused by a passageway blockage and usually due to one of the following.

·        Throat weakness, causing the throat to close during sleep.

·        Mis-positioned jaw, often caused by tension in the muscles

·        Fat gathering in and around the throat

·        Obstruction in the nasal passage way

·        The tissues at the top of airways touching each other causing vibrations

·        Relaxants such as alcohol and drugs relaxing throat muscles

·        Sleeping on one’s back, this may result in the tongue dropping to the back of the mouth.

·        Enlarged tonsils.

·        Age: As u reach middle age and beyond, your throat becomes narrower and the muscle tone in your throat decreases

·        The way you are built, men have narrower air passages than that of women and are more likely to snore. A narrow throat, a cleft palate, enlarged adenoids, and other physical attributes (which contribute to snoring) can be hereditary.

·        Nasal and sinus problems. Blocked airways make inhalation difficult and create a vacuum in the throat leading to snoring.

·        Being overweight or out of shape, fatty tissue and poor muscle tone contribute to snoring.

Snoring and Sleep Apnea:

Snoring could indicate sleep apnea, a potentially life-threatening condition that requires medical attention. Sleep apnea is a breathing obstruction, causing the sleeper to awaken to begin breathing again. A person with sleep apnea wakes up many times a night to begin breathing, but usually doesn’t remember it. Serious risks of sleep apnea include sleep deprivation, oxygen deprivation, and depression.

Impact:

 Snoring is known to cause deprivation to snorers and those around them, as well as day time drowsiness, irritability, lack of focus and decreased libido. It has also been suggested that it can cause significant psychological and damage to sufferers. Multiple studies reveal a positive correlation between loud snoring and risk of heart attack (about +34% chance) and stroke (about +67% chance)

Though snoring is often considered as a minor affliction, snorers can sometimes suffer severe impairment of lifestyle. New studies associate loud snoring with the development of carotid artery atherosclerosis, the risk of brain damage and stroke. Researchers hypothesize that loud snoring creates turbulence in carotid artery blood flow closest to the airway. Generally speaking, increased turbulence irritates cells and has previously been impacted as a cause of atherosclerosis.

 Prevalence:

Statistics on snoring are often contradictory, but at least 30% of adults and perhaps as many as 50% of people in some demographics snore. One survey of 5,713 Italians identified habitual snoring in 24% of men and 13.8% of women, rising to 60% of men and 40% of women aged 60 to 65 years. This suggests an increased susceptibility to snoring as age increases.

 Diagnosis:

 Usually, snoring is recognized by a friend or partner who observes the patient sleeping. Besides the “noise” of snoring, more complex conditions such as sleep apnea can be consistent with the symptom of snoring. A sleep study can identify sucks issues. Patients can also assess their own condition to determine the likelihood of such problems based on the severity of their sleeping difficulties.

How You Snore Reveals Why You Snore:

It’s critical to note the different ways you sleep and snore. Sleep positions reveal a lot, and figuring out how you snore can reveal why you snore, when you know why you snore, you can get closer to a cure

· Closed-mouth snoring may indicate a problem with the tongue.

·   Open-mouth snoring may be related to the tissue in your throat

·  Snoring when sleeping on the back is probably mild-improved sleep habits and lifestyle changes may be effective cures.

· Snoring in all sleep positions can mean snoring is more severe and may require a more comprehensive treatment.

Treatment:

 Almost all treatments for snoring revolve around clearing blockage in the breathing passage. This is the reason snorers are advised to lose weight (to stop fat from pressing on the throat), stop smoking (smoking weakens and clogs the throat) and sleep on their side (to prevent the tongue from blocking the throat. A number of other treatment options are also available, ranging from over-the-counter (OTC) aids such as nasal sprays, nasal strips or nose clips, lubricating sprays, and “anti-snore” clothing and pillows, to such unusual activities as playing didgeridoo. However, Snoring is a recognized medical problem and people who snore should always seek professional medical advice before relying on techniques that may mask symptoms (i.e.; snoring) but not the underlying condition.

 The Medical Remedies:

 ·        Continuous positive airway pressure (C-PAP). To keep your way open during sleep, a machine at your bedside blows pressurized air into a mask that you wear over your nose or face.

· Dental appliances, oral devices, and lower jaw positions often resemble an athlete’s mouth guard. They help open your airway by bringing your lower jaw or your tongue forward during sleep.

·Traditional surgery such as Uvulopalatopharyngoplasty (UPPP), Thermal Ablation Palatoplasty (TAP), Tonsillectomy and Adenoidectomy, increase the size of your airway by surgically removing tissues or correcting abnormalities. The pillar procedure is also an effective surgery in which small plastic implants are inserted into the soft palate; scar tissue grows around the implants, stiffening the soft palate which stops vibrations that cause snoring.

· New Developments: Laser-assisted Uvulopalatoplasty (LAUP) and somnoplasty remove parts of the soft palate to reduce snoring using laser or radiofrequency signals. These newer remedies may require further study.

SLEEP APNEA

Episodes of temporary cessation of breathing lasting 10 seconds or longer, which occur during sleep or Repetitive episodes of upper airway occlusion during sleep, with oxygen de-saturation nearly always associated with snoring. Repetitive apneas produce sleep disruption, leading to excessive daytime sleepiness (EDS).

 People with sleep apnea may not be aware of having any problem during the night, but they may be excessively sleepy during the day, with poor memory and difficulty in concentrating. This can interfere with work and social activities, and in children, with school performance.

Severe sleep apnea is a potentially serious condition, because it may result in hypertension, heart failure, myocardial infarction or stroke.

 Types and Incidence:  

Sleep Apnea may be classified as

·        Obstructive,

·        Control or

·         Mixed.

Obstructive Sleep Apnea:

                        This is the most common type and may affect anyone, but more often middle-aged men. As many as one in 100 men between the ages of 30 and 50 may have the condition; the typical sufferer is overweight and a heavy snorer. People with Obstructive sleep apnea who are very obese and excessively sleepy are said to have pickwickian syndrome. Obstructive sleep apnea has been linked with some instances of sudden infant death syndrome.

The most common cause of Obstructive sleep apnea is over relaxation of the muscles of the soft palate in the pharynx (throat). The muscles sag and obstruct the passage of air during sleep. Obstruction to the passage of air may also be caused by enlarged tonsil or adenoids or by abnormally large tongue or small jaw. In all cases, the obstruction to air movement usually causes loud snoring. If a complete obstruction occurs, breathing stops. Failure to breathe triggers the brain to restart breathing, and as breathing recommences, a gasp is produced and the person may awake briefly.

 Control Sleep Apnea:

 In this form, breathing stops because the diaphragm and chest muscles temporarily cease to work, probably as a result of a disturbance in the brain’s control of breathing. Causes include paralysis of the diaphragm muscles and disorders of the brain stem. Snoring is not a predominant feature.

 Mixed Sleep Apnea:

 This is a combined form of sleep apnea. Usually, there is a short period of control sleep apnea, followed by a longer period of obstructive sleep apnea.

 Signs and symptoms:

·   Cardinal symptom is excessive daytime sleepiness (EDS)

·        Loud snoring

·        Complaints of disrupted sleep

·        Repetitive awakenings with transient sensation of shortness of breath or unclear reasons

·        Tired and un refreshed upon AM awakening

·        Witness apneas at night

·        Complaints of poor concentration, memory problems, irritability

·        Morning headaches

·        Short tempered

·        Decreased libido is also common

·        Depression

Causes:

Upper airway narrowing due to enlarged tonsils, adenoids, uvula, low soft palate, large or posterior located tongue or cranio-facial abnormalities superimposed upon a co-existent abnormality of neurological control of upper airway muscle tone or ventilator control during sleep.

Risk Factors:

·        Obesity,Nasal obstruction (due to polyps, rhinitis or deviated septum

·        Hypothyroidism,Acromegaly (enlarged tongue)

·        People with hypertension, cardiovascular or anterior-vascular disease or alveolar hypoventilation have a much higher risk of obstructive sleep apnea (OSA)

“ROREND”

Dose: 1 Capsule in the Morning & 1 Capsule in the Night BEFORE Food. As long as they feel relived and cured.

Mode of action: ROREND – CURES YOUR SNORING ISSUES

·        All the herbal ingredients contain aromatic volatile oils and they exert their action on uvula and soft palate and makes smooth airflow which in turn stops snoring.

·        All these ingredients having sound bronchodilator effects open the throat, reposition the tensed jaw and softens the fat in and around the throat.

·        Clears the obstruction in nasal pathway and relaxes throat muscles

·        Keeps intact a cleft, palate, enlarged adenoids and other physical attributes

·        Clears nasal and sinus problems

·        Clears blocked airways

·        Clears vacuum in the throat.

USP:

·        First time in India

·        All aromatic sources and extracts are from herbal- hence they are safe

·        Simple dosage and duration

·        Quite economical and avoids painful operations

·        No need to use CPAP machine

·        By controlling snoring, one can avoid fore coming heart attack and stroke 

Pharmacology and action:

Vasaka is bitter and astringent in taste. It has been used as an antispasmodic, bronchodilator and mucolytic agent in asthma and other respiratory conditions. It has oxytocic properties and can be abortifacient. It contains vasicine vasicinone that liquefy sputum in a tenacious cough. These two compounds possess bronchodilatory activity and inhibit allergen induced bronchial obstruction. Exhibits antitussive activity and shows strong respiratory stimulant activity. And has platelet increasing activity with vasicine. And also shows uterine stimulant activity and moderate hypotensive activity.

Pippali is a perennial aromatic shrub which has a pungent taste. It contains volatile oil, alkaloids piperine and piperlonguminine, terpenoids and a waxy alkaloid. Pippali is pitta suppressant and vata kapha aggravation. Acts as bronchodilator, decongestant, expectorant, and lung rejuvenative. In the digestive tract, it also has powerful actions as carminative. It is a metabolic stimulant, aiding the thermogenic response by increasing the level of thyroid hormone. In bronchial asthma, the “vardamanpippali rasayana” can be used as described in detail in “charaksamhita”. Recent research confirms the immune-stimulatory and antigiardial effects of Pippali. Also acts as an anti ulcerogenic. Pippali is an anti-cancer agent, anti-tumor promoter, circulatory stimulant and aphrodisiac.

Bilva is astringent and bitter in taste , pungent in the post digestive effect and has hot potency . It alleviates kapha and vata dosha, but aggravates the pitta dosha. It has astringent, anti-diarrhoeal, appetizer and digestant properties. The raw fruit is an appetizer, digestant and an astringent, whereas the ripened fruit is astringent, sweet but mildly laxative in properties. Bilva protects against genotoxicity which may be due to inhibition of free radicals and increased antioxidant status. Bilva shows antiulcer, antidiabetic, anti radio productive, anti inflammatory, antipyretic, analgesic and anti spermatogenic activity.

Ginger contains a number of pungent constituents and active ingredients. The mechanism underlying ginger’s anti-emetic activity is not clearly understood, but the aromatic, spasmolytic, carminative, and absorbent properties of ginger suggest it has direct effects on the gastrointestinal tract.

Yastimadhu is sweet in nature. It has excellent rasayana action in diseases like asthma, bronchitis and chronic cough. Licorice has demulcent action and hence it is more useful in dry –Vata type of diseases. It is specific rasayana for amlapitta and parinam shula – peptic ulcers. Its rasayana action on the gastric mucosa helps to avoid the recurrence of peptic ulcers. If given with shatavari it has the best rasayana action in diseases like cystitis. Charaka has mentioned it as an important rasayana for nerves and the brain.

Indications and clinical uses:

Vasaka is an expectorant and bronchodilator. Useful in acute as well as in chronic cough. Expectorant will help loosen phlegm deposits in the airway. May be applied to wounds for their anti-bacterial and anti-inflammatory properties.Used to control both internal and external bleeding such as peptic ulcers, piles and bleeding gums.Also been used to speed delivery during childbirth.

Pippali fruits are used for diseases like: inflammation, pain, nervous weakness, tastelessness, and indigestion, loss of appetite, constipation, asthma, cough, menstrual disturbances and worms. Pippali oil and paste will reduce inflammation, and powder will help in maintaining proper peristaltic movements. And also tones up the respiratory tract & urinary tract.

Bael leaves are extremely used for treating diabetes, jaundice, cholera and asthma. Bael roots cure fevers, stop pain in the abdomen, the palpitation of the heart, and poverty of the seminal fluid. Bael fruits are very useful in chronic diarrhea and dysentery. The unripe fruits improve appetite. The edematous conditions of the uterus, postpartum infections and leucorrhea are effectively controlled with the decoction of its roots.

Sunthi is aphrodisiac. It clears abdominal diseases and worms, bronchitis or asthma, heart disease, dropsy, cholera, nausea, bad taste in the mouth. It is carminative, diuretic. Good remedy for gastric disorders, rheumatism, fevers and nervous diseases. Good remedy for abdominal distention when it is mixed with castor oil. It relieves the cough and sore throat. Relieves pain, swelling, head-ache and tooth-ache as eternal paste.

Yastimadhu acts as a demulcent with alkaline properties. Root decoction helps to relieve oral inflammations, dry coughs, bronchitis and asthma. As an expectorant it helps to liquefy and expel mucus, cleansing the lungs. It can be chewed on to relieve sore throats and improves voice. Strengthens the immunity, complexion, and promotes hair growth, and has mild laxative properties.

CONTRAINDICATIONS:

Large doses of Vasaka may irritate the alimentary canal and cause diarrhea and vomiting.

Pippali has been contraindicated to be used for a longer duration. And in excess pitta and in other inflammations of the intestines.

Dried fruit of Bilva for constipation, fresh fruit for congestion and weak digestion.

Ginger was contraindicated to be used by pregnant women and THE GERMAN COMMISSION E also mentions gallstones as a relative contraindication for ginger, without citing a rational.

Pregnant women, those with high blood pressure or heart conditions, and in conditions like CCF, edema should not use Yashtimadhu.

Warnings and precautions:

• The product is not for use by pregnant or nursing women or by children.
• Keep this product out of the reach of children.
• Store in a cool and dry place, away from direct light.
• Do not refrigerate and avoid excessive heat.
• Do not use it if the seal is broken.
• Diabetes, hypoglycemic and people with known medical conditions and /or taking drugs should consult with a licensed physician and/ or pharmacist prior to taking herbal supplements.

Adverse reactions:

Use of this product for long periods or at high doses may lead to:

• Vasaka may show adverse reactions like diarrhea, nausea, and vomiting.
• Pippali or long pepper sometimes is a skin irritant.
• Ginger is on the U. S. Food and Drug Administration’s GRAS (generally recognized as safe) list. The British Herbal Compendium documents no adverse effects of ginger
• Yastimadhu shows side effects like rash, itching or swelling, severe dizziness and trouble breathing.

Toxicology and drug interactions:

• Vasaka rated slightly dangerous for those who take larger than appropriate quantities for extended periods of time. Being an herbal supplement no drug interactions are reported.
• It is important to note that in certain situations, the potentiating effect of Pippali may be dangerous in terms of herb-drug interactions. Taking pippali with phenytoin, propranolol (inderal), theophylline may increase absorption and blood levels.
• Bilva has no drug interactions
• Ginger has no drug interactions, due to ginger’s apparent effect on platelets, it should be used cautiously in individuals using anticoagulants.
• Yastimadhu has no drug interactions.

Dosage:

Vasaka:       

• powder of leaves :-                       3-6gms
• Juice of fresh leaves:-                   10-20ml
• Decoction of roots:-                     40-80ml
• powder:-                                         1-2gm
• Liquid extract:-                               1-2ml
• Syrup:-                                             2-4ml

Pippali:

• fruit powder:-                                ½ -1gm
• Root powder:-                               1-2gm
• powder:-                                         1-5gm/day
• Liquid:-                                             5-15ml

Bilva:

• dried fruit powder:-                     1-12gm/day
• Fresh fruit juice:-                           5-15ml/day
• powder:-                                         3-6gms
• Juice:-                                             10-20ml

Sunthi:

• 1-4gms daily

Yastimadhu:

• 250mg twice a day.

 Each capsule contains:

• VASAKA             100 mg
• SUNTHI              100 mg
• YASTIMADHU   100 mg
• PIPPALI              100 mg
• BILVA                 100 mg

Indications: snoring and sleep apnea

Combined Dosage: one capsule twice a day

Mild: 5 Days (10 capsules) 1 strip

          Cost of treatment - Rs.250/-

Moderate: 10 days (20 capsules) 2 strips

                Cost of treatment – Rs.500/-

Severe: 15 days (30 capsules) 3 strips

                +Cost of treatment 750/-

Clinical trials:

            We are here to confirm that we have conducted clinical trials on snoring patients with the product “ROREND” capsules supplied by Gencleus PHARMA LIMITED. After thorough examination of the herbal aromatic extracts used in this capsule we have conducted trails on 62 patients responding for paper advertisement. We have recorded the results with 42 patients only, the rest 20 patients not turned up. We could contact 16 of them over the phone they too reported that there was no snoring from 2nd or 3rd day. The results of four patients are not known. However we have not noticed any side effects with this SNORIL.

           We with our group of 7 doctors participated in this program and concluded that “ROREND” really works without any side effects.